ABSTRACT
Objective Circulating tumor cells (CTCs) have potential value in the clinical application of various tumors. This study was to investigate the role of CTCs and their chemokine receptor CCR9 in the invasion and metastasis of non-small cell lung cancer (NSCLC). Methods From May 2018 to June 2019, a total of 62 patients with NSCLC in the clinical oncology center of The People's Hospital of Guangxi Zhuang Autonomous Region were enrolled in this study. The CanpatrolTM CTC technique was used to detected the expressions of CTCs and CCR9 in CTCs in peripheral blood of patients. Furthermore, the relationships between expression levels of CTCs, CCR9 and clinical, pathological characteristics of NSCLC patients were analyzed. Results CTCs were detected in 56 of 62 (90.3%) NSCLC patients. CTCs counts were associated with TNM stage, lymph node metastasis and distant metastasis of NSCLC (P<0.05). In the analysis of clinical correlation between CTC subtypes and NSCLC, epithelial CTCs counts were related to TNM stage and distant metastasis of NSCLC (r=0.296 and r=0.273, P<0.05). Additionally, counts of mixed type CTCs were also correlative with NSCLC tumor metastasis (r =0.253, P =0.047). Finally, we found that the positive rate of CCR9 in mixed type CTCs was associated with distant metastasis of NSCLC (r=0.353, P=0.038). Conclusion CTCs counts and subtypes were correlated with TNM stage and metastasis of NSCLC. The expression level of CCR9 on CTC was expected to be a biomarker to evaluate the risk of tumor metastasis in NSCLC.
ABSTRACT
@#AIM: To investigate the effects of bandage contact lenses on corneal irritation and wound healing after deep corneal foreignbody removal.<p>METHODS: Forty-six patients(46 eyes)with deep corneal foreignbody removal were divided into two groups(23 patients for each). Both groups received deep corneal foreignbody removal. Patients of group 1 wore bandage contact lenses after the surgery,while patients of group 2 did not receive any further treatment after the surgery. The differences in eye irritation( at 1,3 and 7d)and corneal epithelial healing(at 7d)between the two groups were observed.<p>RESULTS: Mean pain scores were significantly lower in group 1(0.44±0.26, 0.26±0.14, 0.12±0.08)than in group 2(1.26±0.44, 1.02±0.38, 0.68±0.26)at 1, 3 and 7d after the surgery(<i>P</i><0.05). The rate of completely corneal epithelial healing at 7d were significantly higher in group 1(21 eyes, 91%)than in group 2(14 eyes,61%)(<i>P</i><0.05). <p>CONCLUSION: Bandage contact lenses will accelerate the recovery of corneal wounds,improve the healthcare efficiency and effectively alleviate eye irritation.
ABSTRACT
AIM: To evaluate the clinical results of capsular tension ring (CTR) implantation in phacoemulsification for eyes with congenital lens subluxation.METHODS: This study comprised 18 patients (31 eyes) with congenital ectopia lentis.All patients received phacoemulsification with CTR and intraocular lens (IOL) implantation.Visual acuity before and after surgery were examined.IOL decentration were measured with Image-Pro Plus image processing software.The complications were also recorded preoperatively and postoperatively.RESULTS: Uncorrected vision of all eyes increased after surgery, and all cases had different degree of IOL decentration after surgery.Two eyes received CTR scleral fixation 3mo after surgery because the IOL decentration aggravated during the follow-up period.CONCLUSION: Phacoemulsification with CTR and IOL implantation is effective and safe for congenital lens subluxation.The implantation of CTR increase the stability of the capsular bag, improve the safety of surgery, and maintain the right position of IOL.CTR scleral fixation is a effective supplement for progressive cases.